|
Adaptogens.org is not responsible for the compilation of the informaition provided below. We give full credit to its author José A. Olalde Rangel. We have also provided a link to the original document in its entirety on our links page. We only provide this information here to further the reachings of this priceless information.
The Systemic Theory
of Living Systems
by José Olalde Rangel
José A. Olalde Rangel, Author, Engineer
Founder and President
Adaptogenic Educational Medical Centers
Founder Venezuelan Association of Systemic Medicine
Caracas, Venezuela
Tel: 58-212-9459925 Fax: 58-212-9435911
Email: adaptogen@cantv.net
Clarification: Origin of The Systemic Theory of Living Systems
Foreword.
No
one should be subject to untrue or misleading information provided by
one or more individuals who assume as their own intellectual property,
proprietary rights and/or technology -belonging to others- for a
commercial gain or enhancement of personal reputation. Thus, the
purpose of this site is to warn all interested parties that:
(a) The authorship of The Systemic Theory of Living Systems -which in turn led to the creation and origin of Systemic Medicine as described further on - was conceived by Eng. José Olalde who is its author, founder and rightful owner; and
(b) All those who use and cite any of the concepts belonging to the body of work cited in literal (a) without Eng. José Olalde´s written permission are subject to prosecution by the applicable law.
Unauthorized use of intellectual property.-
The
general public should be aware of the presence of websites that claim
to have copyright and intellectual property rights over ideas and
concepts of the Systemic Theory of Living Systems. Some of these sites
include literal extracts of the Systemic Theory, misrepresenting the
true intellectual authorship, copying and altering concepts, without
the prior consent of the true author.
A
non-scientifically inclined reader will have no trouble in finding and
identifying the true concepts in the original work entitled The Systemic Theory of Living Systems described further on.
No man has a monopoly on knowledge.-
The
author of the Systemic Theory believes in freedom of knowledge and in
the right of each man to utilize it to the best of his capacity. In
this basic sense, the Systemic Theory belongs to the world; however,
certain fundamentals like true authorship should be preserved and
respected. Additionally, the author opposes anyone who tries to
misrepresent, monopolize and wrongfully appropriate intellectual
property created for the benefit of mankind.
What is the Systemic Theory
The
Systemic Theory is a methodological, rational and systematic framework
designed to assist living systems in reversing and/or minimizing the
effects of the universally recognized progression of entropy -or chaos-
and reach maximum survival by increasing Energy, Biological
Intelligence and Organization, providing mainly phytomedicines. In
other words, The Systemic Theory postulates principles and strategies
to manage the effects of The Second Law of Thermodynamics: reduction of
available energy and increase of chaos. |
|
TABLE OF CONTENTS |
I. Abstract
|
Pg. 4
|
II. Introduction
• The phenomenological theory: H, F, O and E, I, O.
• Early history and prior developments of the theory
• Life and Entropy: Justification for the use of phytomedicines
|
Pg. 5
Pg. 5
Pg. 5
Pg. 6
|
III. Philosophical approach to Systemic Medicine
• Key Definitions
• The Logic
• Life's common denominator
• I, E, and O as a health triangle
• Example of an I, E & O increase by providing Panax ginseng
|
Pg. 6
Pg. 6
Pg. 6
Pg. 7
Pg. 7
Pg. 7
|
• The Biological Intelligence
• The law of action and intent of greater reaction
• Why cell rebellion?
• Application of Systemic Medicine's Golden rules |
Pg. 7
Pg. 8
Pg. 9
Pg. 9
Pg. 10
|
• Abstract of SM results in Diabetic Foot
• Abstract of SM results in Severe Psoriasis
• Abstract of SM results in Terminal Prostate Cancer
• Abstract of SM results in Chronic Renal Failure
• Analysis of Clinical Results |
Pg. 11
Pg. 11
Pg. 12
Pg. 13
Pg. 14
Pg. 14
|
• Energy axis stimulation
• Organizational axis stimulation
• Intelligence axis stimulation
• Immune
• Cellular
• Biochemical
|
Pg. 14
Pg. 15
Pg. 15
Pg. 16
Pg. 16
Pg. 16
Pg. 16
|
VII. Conclusions |
Pg. 17 |
VIII. References |
Pg. 19 |
IX. Addendums
• Table of Clinical Studies by Pathology
• Graphs w/statistical validation of studies
|
Pg. 20
Pg. 21 |
Top^ |
I. Abstract
The
Systemic Theory is axiomatic. It originates from the phenomenological
idea that physiological health is based on three factors: integrity of
its structure or organization O , functional organic energy reserve E and level of active biological intelligence I . The treatment strategy called Systemic Medicine ( SM )
is based on identifying and prescribing phytomedicines and/or other
medications that strengthen each factor. Energy stimulating
phytomedicines increase available energy and decrease total entropy of
an open biological system by providing negative entropy. The same occurs with phytomedicines that act as biological intelligence
modulators. They should then be used as the first line of treatment in
all ailments, since all pathologies by definition, imply a higher than
normal organic entropy. Systemic Medicine postulates that the state of health H , of an individual, is effectively equal to the product of the strength of each factor H = O x E x I . SM observes that when all three factors are brought back to ideal levels, patients' conditions begin the recovery to normal health . Its
effectiveness is corroborated as an evidence based CAM in abstracts of
clinical studies on Diabetic Foot, Psoriasis, Prostate Cancer and
Chronic Renal Failure, where exceptional results have been obtained:
74% remission in cases diagnosed for amputation in Diabetic Foot; 77%
remission in patients suffering from severe Psoriasis; over 77%
remission in Terminal Prostate Cancer ; 79% improvement or
deterioration detainment in CRF; 83% QoL improvement and over 96%
tolerability to treatments in all pathologies. Included in Addendum A,
is a table with a summary of results of clinical studies in twelve
pathologies. Addendum B summarizes graphs and statistical validation
for results obtained in all studies. Systemic Medicine is a novel
framework to prescribe mainly herbal medicines (in some cases supported
by subtle galenicals, such as homeopathy) for chronic degenerative
illnesses, incurable by conventional biomedicine means. The success of
its application has made it popular throughout Venezuela . Over 200,000
patients have been treated by 150 MD's in 30 medical establishments
with promising results. Aligned with the Hippocratic Oath and the
Declaration of Helsinki, SM proposes a simple, more humane, rational
approach and a non iatrogenic therapy, coincident with Dr. E.L. Cooper
–editor in chief of eCAM journal- who notes: `…with all its successes
modern Western medicine also has limitations such as unbearable side
effects, high medical costs, facilities that are not accessible to
everyone and ethical problems …´.
|
II. Introduction
• The phenomenological theory: H, F, O and E, I, O .
Fire H, F, O: At the end of the 18 th century, Antoine-Laurent Lavoisier (1743–1794) unveiled the mystery of
fire, discovering that its anatomy -and minimum common denominator-
constituted a triangle whose sides corresponded to heat ( H ), fuel ( F ) and oxygen ( O ).
Lavoisier also deducted the biconditional characteristic of fire, i.e.,
it can occur if and only if all three elements are present, H, F, O Fire. Since then the fire triangle has been the foundation of all firefighting techniques.
Life E, I, O: The Systemic Theory was conceived by the author in 1995, while pursuing a unified theory of living systems . (1) As
result of an engineering background, an interest in philosophy, health,
phytotherapy and knowledge of the General Adaptation Syndrome (2 ) , he recognized in energy ( E) , intelligence (I) and organization (O) a minimum common denominator in living systems, of a triangular
anatomy, analogous to the fire triangle; establishing that a biological
system can only exist, if and only if, all three elements were present,
and vice versa: E, I, O Life . The author proposed its application in the field of phytotherapy (3) and medicine (4) ,
in two local bestselling books, which created interest within the
medical community and resulted in the creation of the first medical
center. The application consisted in classifying and applying herbs
according to: Energy stimulating properties; Biological Intelligence
modulators; finally, organizational (structural and functional)
pathologically targeted enhancers. Energy , Intelligence and Organization structure a common denominator of life that answers an age old
question: what is the difference between a dead animal and a living
one? Answer: A dead animal has no Energy, no Biologic Intelligence nor
Organizational Function. A sick animal has diminished levels of these
three elements, while a healthy one has all three in suitable amounts. |
|
|
B. Early history and prior developments of the theory
Aggressors –or stressors- were identified by Professor Hans Selye, and
reflected in over 1500 articles and 32 books. He formulated the General
Adaptation Syndrome (GAS) (5) which classified effects on animals and humans affected by threats (exhaustion, disease, fear, extreme cold…) as: Alarm (body's recognition of danger and its preparation to deal with threats); Resistance (also defined as adaptation, in which the body adapts to resist stress); and Exhaustion (condition
in which the body's energy supply is depleted). The next step was taken
by Soviet scientists led by Lazarev and Brekhman, who investigated
properties of substances, which they called adaptogens. By 1960 more
than 1000 studies had been published by Soviet scientists concerning
the use of adaptogens. |
Fig. 1 |
In 1962, Eleutherococcus senticosus , Rhaponticum carthamoides and Rhodiola rosea -all adaptogens- were included in the Soviet Union 's Pharmacopoeia.
Since then many other plants and sources have been found to have the
same properties. (6 - 9) The new phytomedicines increased resistance to stressors as depicted by Selye (2) , enhancing energy, and regulating immune, neuroendocrine and cellular function. Figure 1 is the author's interpretation of E (Energy drop) in relation to Selye's description of biochemical collapse I and organic dysfunction O. The latter also paved the way to the E , I and O triangle –explained further on- and the Systemic Theory.
C. Life and Entropy: Justification for the use of phytomedicines
The
second law of thermodynamics states that a system naturally tends to go
from a state of higher energy and order to one of lower energy and
disorder. The same occurs in living systems whose internal entropy
tends to increase in its journey through life, going from health,
energy and physiological order towards sickness, asthenia -the loss or
lack of bodily strength; weakness- and physiological disorder. Illness
however can be countered based on Erwin Schroedinger's (1887-1961)
notion that the general change of entropy in an open system, such as a
living system, consists of (a) internal entropy variations and (b)
entropy exchange of the system with the environment; i.e., dS = dS
internal + dS exchange. Internal entropy in a biological organism, by
definition, tends to be greater than zero due to inner irreversible
processes. Therefore, the increase in entropy of an open biological
system, and thus illness, may be reduced (10) providing negative entropy from the environment. ‘…The
decrease of entropy in living systems is provided by free energy,
released when nutrients consumed from the outside dissociate, i.e., at
the expense of the sun's energy. Thus the flow of negative entropy is
important to compensate for inner destructive processes and the
decrease of available free energy dissipated by spontaneous metabolic
reactions. This is the key point, circulation and transformation of
free energy, which drives the functions of living systems…' (11)
Top^
III. The Systemic Theory of Living Systems
A. Key Definitions
Several definitions are essential as the theory emerges. Logic is defined as a correct reasoning that forms the basis of any science. Living System is
a unit comprised of elements that work in a coordinated manner, each in
service to the other, to achieve the common goal of survival. This
definition applies to bacteria, viruses, ant colonies, persons, groups,
institutions or countries. Intelligence (I) is the regulating
entity that controls and integrates parts of a living system, in a
functional unit, directed and geared towards survival. Energy (E) is any fuel that causes action or movement, also defined as that which makes things occur. Organization (O) is a group of elements ordered as a functional unit, directed towards goals established by the intelligence that rules them. In
a living system, the functions performed by I, E and O are similar to
functions carried out in a moving vehicle, by driver, fuel and the
vehicle itself.
B. The logic |
|
All living systems are, by definition, functional units that seek maximum survival (12) The cell is the simplest form of a living system that functions as a basic building block of the living universe, just as the atom does in matter. (Figure 2) Conversely, a virus is the simplest living unit that in some situations acts as destroyer of the living system . The Intelligence (I) is the backbone of living systems in equilibrium. ‘I' controls, regulates, adapts and develops the living system.
|
Fig. 2 |
Chaos occurs in its absence. The proof of this is that no living system can exist without intelligence. The intelligence of the system creates and utilizes E with the prime role of achieving O and evolving into a higher system. (13)
I also creates/builds O with the primary end of producing E . There may be a corollary: As a consequence, I cannot act optimally when subjected to a severe E deficiency.
C. Life's common denominator |
|
The common denominator in all living systems is the trio: I, E, and O. This is a self evident truth and an essential condition to all living systems in the known universe. I, E and O constitute a triad, because none of its constituent elements can exist without any of
|
Fig. 3 |
the other two. The trio I, E, O has, in fact, a triangular anatomy, since when any member of the trio – I, E, O -
decreases, the other two decrease as well (a synthetic drug such as
methylphenidate diminishes the immune intelligence, thereby decreasing
the other two members).
When any member I, E or O increases – for example Panax Ginseng raises immune intelligence (14) – then the other two also increase as well (15) However, this increase is synergic, for the boost in any of I. E and O results in a greater triangular anatomy of the new trio (Figure 3) . Finally, if any one member of the trio disappears, the system dies. The triangle I, E, O reflects the survival status of a living system, corresponding to an organism's health. Health (H) is herein defined as the survival potential. (Figure 4) |
Fig. 4 |
D. I, E, and O as a health triangle
In every living system I , E , O constitute the three essential sides of a triangle. (16 - 18) This triangle corresponds to the survival phenomenon, where each side constitutes a different aspect of survival.
Together they represent a measure of the survival potential, which by definition is the H of the system. The
survival potential or amount of H in any living system can be defined
as the mathematical product of its amount of E, I and O. Thus, survival potential = H = E x I x O. It is possible to increase the survival potential H of a living system, by increasing any of its three essential elements.
Similarly H can be reduced by a cutback in any of its fundamental
components. The E , I , O triangle is not
equilateral, because the system's intelligence acts as generating
entity. It is not necessarily a two dimensional triangle either. It may
be spherical, elliptical or hyperbolic. However, the determination of
this was not essential to develop the systemic technology. Finally: I is the most important side of the triangle, since it concurrently generates both energy and organization. (19) |
|
|
E. Example of I, E & O increase by providing Panax ginseng |
Panax active principles are bonded to beta-adrenoceptors in the cellular
membrane, triggering a secondary transmitting message system (cyclic
AMP), the signal travels through a transducer pathway to the
mitochondria to increase activity of MDH, SDH and CTS, enzymes of the
glycolysis or tricarboxylic acid cycle. This heaves ATP generation, increasing energy levels using glucose as fuel. ( Figure 5 ) Moreover ginsenosides such as the sulfonylureas, are insulin secretagogues (I stimulators) since they help regulate blood |
Fig. 5 |
glucose levels by directly stimulating first-phase insulin secretion in the pancreatic beta cells (O) .
These cells are responsible for sensing and secreting appropriate
amounts of insulin in response to a glucose stimulus. Mitochondrial
glucose metabolism leads to ATP generation and increases intracellular
ratios of ATP/ADP, that result in closure of the ATP-sensitive
potassium channel (K ATP ; a 140 kDa membrane protein) on the plasma
membrane. |
Closure of this channel depolarizes the membrane and triggers opening
of voltage-sensitive calcium channels, leading to the rapid influx of
calcium. Increased intracellular calcium causes an alteration in the
cytoskeleton and stimulates translocation of insulin-containing
secretor granules to the plasma membrane -and the exocytotic release of
insulin. |
|
Increase
in the ATP/ADP ratio or binding of ginsenosides to cell membrane
receptors results in the closure of the K ATP channel and insulin
secretion. (20) This is depicted in Figure 6 .
As a corollary, increasing energy we obtain a significantly larger
Health Triangle because the System's Intelligence has acquired more
capacity to organize. Panax ginseng provides an example of a phytomedicine capable of enhancing I, E and O simultaneously in the living system.
|
IV. Expansion of the Systemic theory to the Human Body
Ideal
medicine , natural or synthetic, is that which has the capacity to
increase I , E , and O in the oppressed human body; i.e., all ideal
medicines should provide negative entropy. (11) Non-optimal medicine, whether natural or synthetic, is that which
though enhancing one or two sides of the triangle, simultaneously
suppresses the remaining side(s). This is referred to as secondary
and/or side effects.
A non-optimal medicine provides positive entropy (disorder and decrease in energy availability).
A. The Biological Intelligence |
The common denominator of human Biological Intelligence BI is constituted by the Immune Intelligence I I , Cellular Intelligence I C and Biochemical (Neuro-endocrine) Intelligence I B respectively. These three elements constitute a triad since none of them can exist in the absence of any other: The Immune Intelligence I I cannot exist without the I C that generates it, nor without the I B that allows its communications (21-23) and maintenance . The Biochemical Intelligence I B cannot live without the I I , and vice versa, since there is a proven bidirectional relationship and crosstalk between both . (21-23) Likewise, I B cannot exist without I C (axiomatic). The Cellular Intelligence I C is that entity which regulates genetics and metabolism of all and each
organic cell. It generates the immune system with the primary function
of protecting the cellular system from pathogens. I C cannot exist in absence of an I I that protects it, nor without the I B that sustains and allows for information exchange; this is self
evident. It is postulational that a collapse of either the biochemical
or immune media directly affects the cellular system. It is the most
important side of the triangle. |
The geometrical anatomy of the Biological Intelligence BI constitutes a triangle, since I I , I C , I B are different manifestations of the biologic intelligence phenomenon. (Figure 7) This rationale is consistent with the argumentation of the Health triangle ( H ). If any of the trio's members disappears, the other two members die, the BI ceases to exist. When any one member of the triangle decreases the other two decrease. However, when any |
Fig. 7 |
member of the BI increases the other two increase –in a synergic manner- as well. The triangle that conforms the BI is not equilateral because I C predominates, being the generating entity of both I I & I B . As in the Health triangle, BI is not necessarily a two dimensional triangle.
It could be spherical, elliptical, hyperbolic or other. BI is in optimum state when I I , I C and I B are generating homeokinesis. The healing potential of BI can be defined as the mathematical product of its immune strength, genetic state and neuroendocrine condition; i.e.: BI (HEALING POTENTIAL) = I I * I C * I B . It is possible to enhance BI by increasing any of its three essential
components. This can be achieved, for example, with immune modulators. (21) (24 - 25) The opposite also holds true, a collapse of any component will impact the other two. Negative life impacts are all those aggressors of physical, chemical or biological nature that increase the body's organic entropy, suppressing BI which generates physiological disorder (serious illness) and brings
about eventual death. Most chronic diseases are caused by negative life
impacts that deactivate the BI. It is indispensable to
reactivate the BI in order to heal the organism from `incurable´
chronic diseases. In many cases it is possible to rehabilitate the BI with phytomedicines -suppliers of free energy and negative entropy- and homeopathic remedies that stimulate I I , I C , I B . It is also possible to reestablish the BI with spiritual aid when the origin of the sickness is emotional, i.e.,
when the pituitary and pineal glands are oppressed by mental duress of
emotional origin. In fact, in pathologies of mental origin, spiritual
aid should be the first line of treatment. The BI is capable of
healing the organism if it is activated and if it has availability of
active principles, vital for manufacturing energy and achieving
biological organization. If the BI cannot be activated , the cure of the organism will not be achieved even though E and O resources may be available.
|
B. The law of action and intent of greater reaction (26)
When
intelligent aggressor agents try to reduce the H of a living system,
the targeted system's I tries to generate an opposing but greater
reaction with the purpose of surviving. The survival strategy of the
targeted system consists in trying to increase its I, E and O, levels
while simultaneously trying to weaken the opposing (aggressor's)
survival triangle. If the former can be achieved, the targeted system's
I survives and thus the affected system survives.
|
This
law constitutes the basis of immunology, homeopathy and hormesis. It
also gives an insight into the reaction of a tumorous cell in Cancer. |
|
|
|
Health
implies optimum survival. Optimum survival can be defined as the
optimum velocity at which the system reacts increasing I, strengthening
O and making available sufficient E allowing the system to overcome and
counter aggressor agents. Sometimes this is also called successful
adaptation or even evolution. If this is not achieved the result will
be a collapse of the system. |
Fig 8 |
|
One
example of optimum survival is tumor suppressing genes that react
regularly to vanquish frequent cellular proliferation caused by proto
oncogenes in a healthy body. The onset of `incurable´ disease occurs
when the BI is overwhelmed by pathogens. (Figure 8)
The cycle of the `incurable´ disease is: |
|
AGGRESOR Agent Biological Intelligence (WEAKENING)`INCURABLE´ |
|
It is medically proven that neoplasm (cell rebellion) in a great number
of cases occurs when the incurable disease aggravates due to a collapse
of BI. Hence, the cycle of many -if not all Neoplasia- is the following: |
|
AGGRESION Biological Intelligence (COLLAPSE) NEOPLASM REBELLION |
|
C. Why cell rebellion? It
is axiomatic that each cell is a living entity that reacts
intelligently (adapts) to a dangerous and unbalanced organic
environment. Neoplasm is a result, i.e., a defense mechanism, of the
cell's search for maximum survival, when the body's natural defense
mechanisms have collapsed. In other words, the cell generates
neoplasia, to achieve genetic survival, when menaced by anarchy and
chaos in a high entropy system (27) that is disintegrating under the strain caused by stressor agents. Based on the former, neoplasia (Cell rebellion) occurs when as result of aggressors a system undergoes critical chaos. Very high biological entropy, i.e., critical organic disorder (O) , induces low functional energy reserves (E), collapse of the system's intelligence (BI) and a greater probability of cancer (CANCER). Limit ORDER CHAOS System = BI ( COLLAPSE) = CANCER RISK
Hence,
the triad Aggression, Collapse and Neoplasia (Cell Rebellion) (28)
constitute a common denominator in cancer. It also constitutes a
triangle: |
|
AGGRESSION, COLLAPSE, and CELL REBELLION = CANCER |
|
Proof of existence of a triangular condition in cancer: The greater the aggression, the larger the extent of BI collapse and probability of cell rebellion. The more BI collapses, the greater the aggression of pathogens and the more
probable becomes cell rebellion. The stronger the rebellion, the more
pronounced is BI's disintegration and greater the aggression of
opportunistic pathogenic agents. (Figure 9) |
Fig. 9 |
Necessary conditions to cure cancer and break the vicious triangle:
- E enhancement with ATP stimulating herbs that generate an entropy decrease ;
- Neutralize the BI's pathogen or aggressor that triggered the collapse and chaos;
- Rehabilitation of the BI (27) to counter rebel cells and reestablish order;
- Non Iatrogenic Tumor destruction (29) such as electrotherapy (30) and/or localized surgery, if possible.
D. Application of Systemic Medicine's Golden rules
The final objective of Systemic Medicine´s golden rules is to provide negative entropy to the living system. The
Golden rules provide the criteria to include phytomedicines so as to
cover -and rehabilitate- all three sides of The Health triangle.
Golden Rule # 1: Any and all therapeutic formulae should include: Energy inducing phytomedicines providers of life fuel -ATP- (6) (31-32) and herbs or other medicines targeted to correct the specific sickness.
Golden Rule # 2: The nature of the sickness is determined by the first affected side of
any of the two triangles: (E, I, O) or (Immune, Biochemical, Cellular).
Golden Rule # 3: The solution to sickness
requires that the first affected side of the triangle be treated with
the greatest emphasis, since that is the origin of the sickness.
Golden Rule #4: The
etiology of most pathologies -not all- lies in a collapse of the
Biological Intelligence. Thus it is vital to include in most protocols
phytomedicines that strengthen the Biological Intelligence. |
|
V. Four clinical validations of Systemic Medicine
It
must be noted that many traditional and herbal therapies are based on
empirical knowledge, lacking ‘scientific' evidence and passed on by
word of mouth.
This wisdom is not derived from a
structured system of prescription which can be easily put to work by
conventionally trained doctors, practitioners and health care
administrators. Additionally, this knowledge -some of which is based on
legend and belief (33) - is not easily made
available, being somehow restricted to a network of a chosen few. The
majority of which have inherited an extensive family background in
traditional medicine. (34) The Systemic Theory allows herbal practice to be systematized. (3) The
following sections illustrate Systemic Medicine's effectiveness as
evidence based CAM in four different pathologies -Diabetic Foot,
Psoriasis, Prostate Cancer and Chronic Renal Failure. Additionally, an
abridged summary of twelve clinical studies -in different pathologies-
in included in Addendum 1. Systemic Medicine is a novel framework to
prescribe mainly herbal medicines (in some cases supported by subtle
galenicals, such as homeopathics) for chronic degenerative illnesses,
incurable by conventional biomedicine means. It is based on an integral
systems approach to understanding health. The treatment strategy is
based on identifying and prescribing herbs or other medicines that
strengthen Energy, Biological Intelligence and Organization -structure
and function. The main premise is that when all three factors are
brought back to ideal levels, patients' conditions begin the recovery
to normal health.
A. Abstract of SM results in Diabetic Foot - retrospective study of 91 patients.
In this study (35) the following parameters were evaluated in this study: clinical examination by physician; self assessment regarding QoL (36) ; Wagner Scale of Severity grading (37) ; and patient's glucose levels in plasma. All measured before, during and
after treatment. Glucose tolerance curve was not measured. In some
cases Glycosylated hemoglobin and kidney function tests were performed.
Study concluded June 30 th , 2004, in the AEMC,
Caracas , Venezuela . Prior to SM, all subjects had been receiving
conventional therapy without satisfactory results . 43% of all patients
-39- were graded 3 to 5 , i.e., high probability of amputation. Length
of therapy: 15-90 days. Table 1 summarizes results. |
Table 1: Synopsis of Diabetes Study |
Element |
Nº of Patients |
% Patients |
Results and Conclusions |
Clinical Improvement |
70 |
77 |
Scar tissue formation, closing of wounds, downgrading in wound severity… |
Amputation prevention |
29 |
74 |
In 29 out of 39 patients graded 3 to 5
|
Tolerance |
88 |
96.7 |
Patients who did not tolerate treatment -3- had previous gastrointestinal ailments |
Quality of life improvement |
76 |
84 |
Patients increased QoL from poor to good
|
Ambulatory Therapy |
91 |
100 |
All cases were treated on ambulatory basis.
Even better results are to be expected through a strict Hospital based therapy control |
Conventional Therapy |
91 |
100 |
All patients continued their conventional therapy (insulin, antibiotics…) |
Systemic Medicine |
91 |
100 |
All patients complemented therapy w/SM |
|
|
It
is noteworthy that amputation was prevented in 74% of all cases graded
3 to 5, and complete healing was achieved in all cases . In others,
improvement obtained in QoL, without full symptom remission or
disappearance, is enough to consider the application a success, proving
its workability on this pathology.
B. Abstract of SM Results in Severe Psoriasis - retrospective study of 123 patients.
A retrospective study (38) was
carried out on 123 patients suffering a severe Psoriasis i.e., more
than 25% of the body surface covered by plaque, limitations in mobility
due to effects of disease in limbs and altered emotional state which
prevented subject from normal activities. Clinical improvement -size
and number of wounds, improvements in psoriatic signs- tolerability and
improvements in QoL (36) were evaluated. Treatment was carried out at AEMC´s, between April 2002 and
July 2004. Average age was 43.3 yrs. (standard deviation 15 yrs.)
composed of 59% male and 41% female patients (results in Table 2) |
|
Table 2: Synopsis of Severe Psoriasis Study |
Item |
Nº of Patients |
% |
Results and Conclusions |
Clinical Improvement |
95
26
2
Total 123 |
77.3
21
1.7
100 |
? Substantial improvement
? Stable clinical condition
? Exacerbated clinical conditions |
Time for Improvement |
63
32
Total 95 |
66.3
33.7
100 |
= 45 days
> 45 days |
Quality of Life |
102
21
Total :125 |
82.9
17.1
100 |
- QoL improvements (36) |
Tolerability |
123 |
100 |
All patients tolerated well their treatment |
|
|
None
of the patients continued their allopathic treatments. Systemic
Medicine was applied as an alternative therapy, demonstrating
effectiveness in tackling this chronic disease. Clinical improvement,
QoL enhancement and perfect tolerability to protocol were outstanding
results of this therapy.
C. Abstract of SM Results in Chronic Renal Failure - retrospective study of 122 patients. (39)
Inclusion criteria: patients of any age or gender with a CRF diagnosis, who
followed treatment, were examined and controlled at AEMCs. Most
frequent cause of CRF was arterial hypertension with 35%; Diabetes
Mellitus was next (25 %). The rest of the population was associated
with glomerular-nephritis, kidney cysts and renal lithiasis. Bellow is
patient classification and results- Tables 3.1 and 3.2 . |
|
Table 3-1 Patient classification according to CRF severity grading |
Severity |
Creatinine clearance rate (ml/min) |
Nº of patients |
% |
Gender – Average age |
Slight |
30-70 |
19 |
16 |
F : 8; M: 11 – 51 yrs.
|
Moderate |
15-30 |
47 |
38 |
F : 21; M: 26 - 51 yrs.
|
Severe |
10-15 |
28 |
23 |
F : 17; M: 11 - 51 yrs.
|
Terminal |
< 10 |
28 |
23 |
F : 9; M: 19 - 57 yrs. |
|
|
Table 3-2 Synopsis of CRF Study Results |
Evolution |
Slight |
Moderate |
Severe |
Terminal |
|
Patients |
% |
Patients |
% |
Patients |
% |
Patients |
% |
|
Improvement |
0 of 19 |
0 |
16 of 47 |
34.04 |
19 of 28 |
67.85 |
17 of 28 |
60.71 |
Deterioration detained |
14 of 19 |
73.68 |
22of 47 |
46.8 |
7 of 28 |
25.0 |
11 of 28 |
39.28 |
Deteriorated |
5 of 19 |
26.32 |
9 of 47 |
19.14 |
2 of 28 |
7.14 |
0 of 28 |
0 |
QoL Improvement |
15 of 19 |
78.94 |
40 of 47 |
85.1 |
27 of 28 |
96.42 |
27 o 28 |
96.42 |
|
Conclusions in CRF: Independently
of severity, progression of illness was stopped in 54 of 122 patients
(44.3%) -based on individual creatinine clearance rates. SM
demonstrated to be particularly effective in the more advanced stages
of this pathology. Clinical improvements were 67.85% -severe stage- and
60.7% -terminal cases- with upgrading to less severe stages. This
raises a possibility of bypassing substitutive renal therapy in those
patients. SM therapy improved QoL (36) in
all CRF stages. In slight and moderate cases, QoL improvement was 78.9%
and 85.1% respectively. In severe and terminal groups it was 96.4% for
both. Tolerability was excellent: 1 patient had light gastric symptoms
which did not warrant suspension of therapy. Tests showed a
regularization of renal function in 4 patients after 6 months´
treatment, suggesting nephroprotective and nephroregenerating
capabilities of SM therapy .
It also hints that a
longer application of this therapy could lead to renal function
reestablishment in more patients. Results suggest that this therapy
offers unexpectedly superior benefits to patients with CRF.
D. Abstract of SM results in Terminal Prostate Cancer -retrospective study of 30 patients
A retrospective, multicenter, prostate cancer study in 30 patients (40) who
complied with inclusion criteria and graded D2 according to the
Whitmore-Jewett classification method -with distant lymphatic
ganglions, bone(s) and/or viscus organ(s) metastasis- measured the
following: urinary symptoms, bone pain, PSA, QoL and tolerability.
Average age was 68.7 years, standard deviation was 8 years. Inclusion
criteria: Patients followed treatment and attended appointments at
AEMC´s. Table 4 resumes results. |
|
Table 4 : Synopsis of Prostate Cancer Study |
Description |
Patients |
(%) |
Results and Conclusions
|
Urinary symptoms before treatment |
Symptomatic |
19 |
- |
Disurya, mictional flow, urinary retention and frequency… |
Non-Symptomatic |
11 |
- |
|
Total |
30 |
100 |
|
Urinary symptoms after treatment |
Improvement |
15 |
78.9 |
Significant improvement reported |
Non-Improvement |
4 |
21.1 |
|
Total Symptomatic |
19 |
100 |
|
Bone pain before treatment |
Symptomatic |
26 |
|
Referred as having generalized arthralgic pain. |
Non-Symptomatic |
4 |
|
|
Total |
30 |
|
|
Bone pain after treatment |
Improvement |
23 |
88.4 |
Referred as having a satisfactory evolution. |
Non-Improvement |
3 |
11.6 |
|
Total Symptomatic |
26 |
100 |
|
PSA after treatment |
Improvement |
23 |
88.4 |
- 14 patients lowered psa to normal values: psa (pat) = 4
- Average psa improvement ? 75.6 % (decrease)
- Standard Deviation = 26.7 % |
Non-Improvement |
7 |
11.6 |
|
Total |
30 |
100 |
|
QoL after treatment (Grogono-Woodgate) |
Improvement |
26 |
86.6 |
|
Non-Improvement |
4 |
13.4 |
|
Total |
30 |
100 |
|
Tolerability to treatment |
Yes |
29 |
96.6 |
|
No |
1 |
3.4 |
One patient referred headache which did not warrant suspension of treatment |
Total |
30 |
100 |
|
|
D. Analysis of Clinical Results
The retrospective studies elaborated in four different pathologies of distinct etiology revealed:
-74% remission in cases diagnosed for amputation in Diabetic Foot.
-77% remission in patients suffering from severe Psoriasis.
-79% improvement or detainment of the pathology was observed in CRF .
-79%, 88% and 77% improvement in Urinary, Bone symptoms and PSA respectively in TPC.
-83%-89% QoL improvement in all pathologies.
-96-100% tolerability to treatments in all pathologies.
All
patients had received orthodox medications and treatment prior to SM
which had not detained progression of the disease. In these cases
systemic therapy became a treatment of first choice. Moreover, for
Psoriasis and Terminal Prostate Cancer, systemic therapy became the
only alternative for patients. |
|
|
VI. Description of a Systemic Protocol: Diabetic Foot
The formulation of a Systemic protocol is based on the application of the golden rules to stimulate both the Health triangle and its implicit Biological
Intelligence Triangle. Md´s trained in systemic technology would decide
the adequate dosage for each case, depending on a clinical evaluation
to determine degree of injury. The Diabetic Foot protocol -to stimulate the E , O and I - is explained in this section. Inclusion of all protocols would go beyond the breadth of this work. (Figure 10) |
Fig. 10 |
|
A. Energy axis stimulation
Leuzea carthamoides Its active principles are phytosterols -ecdysone family- which activate
synthesis of enzymes that participate in cellular ATP synthesis whose
hydrolysis generates energy . (31)
Eleutherococcus senticosus increases
energy by augmenting oxygen transfer to the muscles, reducing
glycogenolysis and production of lactic acid and pyruvate during
exercise. It also increases the activity of enzymes that participate in
ATP generation. (32)
Pfaffia paniculata As in Leuzea, one of its active principles ( b- ecdysone) facilitates cellular
oxygenation, activates the synthesis of enzymes that participate in the
cellular energy production. (41)
Panax ginseng Its E boosting properties are related to ATP generation, increasing energy levels using glucose as fuel. (32)
B. Organization axis stimulation
Gingko biloba Its
-flavonolglicosides, bioflavonoids, ginkgolides and bilobalides-
increase vascular flow by reducing arterial plaque, stimulating nitric
oxide synthesis and release by increasing CA2+ in vascular endothelial
cells (42) . Vasodilator substances like prostacyclin are liberated (43) , preventing synthesis of pro-inflammatory compounds. This protects the endothelium and reduces its permeability , capillary fragility, accelerates collagen and mucopolysaccharide s
synthesis. These mechanisms enhance blood flow, nutrients and oxygen
vital in treatment of diabetic microangiopathy, cause of diabetic foot
injuries. (44)
Vaccinum myrtillus Anthocyanosides
of this plant reduce deposits of arterial plaque, stimulate liberation
of vasodilator substances like prostacyclin (45) that protect endothelium (46) , inhibit platelet aggregation (PGI2) (47) and prevent
the synthesis of pro-inflammatory compounds. These mechanisms enhance
blood, oxygen and nutrient intake vital in treating microangiopathy
cause of diabetic foot wounds. (48)
Hydrastis Canadensis Its components- berberine, hydrastine and canadine- produce vasodilatation . (49-51)
Ruscus aculeatus Ruscogenins
and flavonoids exert protective effects on capillaries, vascular
endothelium and smooth muscle, strengthen blood vessels, reduce
capillary fragility and help improve arterial circulation. (52) They also cause an increase in neutrophil adherence. (53)
Hydrocotile asiatica The
active principles of this plant -Asiaticosides and triterpenes -
modulate collagen synthesis acting on the fibroblast growth factor of
connective tissue, in vascular walls and vessels. This improves distal
circulation in cases of diabetic microangiopathy . (54)
Craetagu s oxycantha Oligomeric
proanthocyanidines produce arterial vasodilation increasing integrity
of blood vessel wall, improving blood flow and enhancing oxygen use. (55) Stimulate NO levels producing vasorelaxation, decreasing platelet aggregation and adhesion, and inhibiting LDL oxidation. (56) The former protects against atherogenesis and thrombus formation. It contains natural IECA inhibitors . (57)
C. Intelligence axis stimulation
1. Cellular
Panax ginseng The active principles -ginsenosides- enhance I c by stimulating pancreas's beta cells to increase insulin production and the number of insulin receptors. (58) Panax helps glucose reduction needed in diabetic patients. (59) Ginsenosides , as well, have a glycation inhibitory activity that benefits diabetic neuropathy and other diabetic complications. (60)
2. Biochemical
Petiveria alliace Its main
active principle D-pinitol can exert insulin like effects diminishing
glucose level acting via a post receptor pathway of insulin action
affecting glucose uptake. (61)
Ganoderma lucidum . Ganoderan B -a glycan- and other polysaccharides stimulate the neuroendocrine intelligence - I B - by an insulin releasing activity due to Ca2+ inflow facilitation to pancreatic beta cells. (62) . It
improves non-specific humoral and cellular immune response.
Additionally, it contains betaglucans and Germanium which stimulate cellular immunity . (63 - 64)
3. Immune
Grifola frondosa .
Its betaglucans activate dendritic cells that act as antigenic and
citotoxic stimuli also rouse non specific humoral immunity, increasing
levels of interleukin -1, 2, 6, 8- tumor necrosis factor and
interferon, improves T CD4/CD8 cellular relation. (64 - 65) Figure 11 shows probable pathway for plant's active principles.
|
|
|
|
VII. Conclusions
Improvement
or prevention of disease, based solely on the allopathic approach of
treating structure and function is deficient. Must we replace
conventional with alternative medicine? Do common drugs suppress E, I,
O?
In many cases the answer is YES . For example, some traditional herbs produce the same action as NSAIDs without inhibiting E, I, O . Synthetic COX-2 inhibitors tend to negatively affect E, I, O . Vioxx® -Rofecoxib- was pulled off the shelves due to increased risk of heart
attack and cardiovascular events. Similar issues have been documented
for Celebrex® (Celecoxib) and Bextra® (Valdecoxib) . ( 66-69) Why risk it with such drugs when there are safe herbal COX-2 inhibitors? Harpagophytum procumbens (70) , Morinda citrifolia (71) , Tribulus terrestris (72) , Hydrastis canadensis (73- 74) and Uncaria tomentosa (75) all act as NSAIDs, have a multiplicity of beneficial actions and no side effects. Immune modulators (76-77) may work wonders for I by substituting steroids –totally or partially- in autoimmune diseases.
In some cases though, common drugs may be necessary. A prompt use of
antibiotics in a very strong infection may save a life. The big tragedy
however are most cancer treatments, that work mostly in the wrong
direction by oppressing H , while excluding potent herbal E or I stimulants (21)(24-25) as well as Electrotherapy (78) which has proven
to be highly effective in solid tumors. Equally harmful are high
entropy anti-depressives, Psychiatric Electroshock and HRT. These are
but some reasons why many patients are shifting to alternative medicine.
On Chronic Illnesses : In all degenerative sicknesses the deficiency of functional organic E reserves as well as biologic I dysfunction should be corrected if a therapy is to achieve acceptable
results. Thus: Medicine should not ignore the fundamental need to
understand and stimulate E or biologic I by all means, in all chronic
illnesses, to enhance living systems. The latter is aligned with
`…obtain a broad understanding… of the way the neuroendocrine system
evolved, its functions and coordination with other body systems…´ (52) Systemic Medicine
has proven to be effective in the treatment of four pathologies of
completely distinct etiology according to the orthodox perspective;
however, this is not correct from the systemic viewpoint. What do all
pathologies have in common? All pathologies can be seen to have one
common denominator and one common etiology: a collapse of E , I or O ,
induced by an increase in external entropy caused by suppressor agents
-of biological, chemical, physical or emotional nature- or by an
increase in internal entropy due to aging, or in exceptional cases
genetic inheritance. Similarly then, all pathologies, in theory, should
be reversible or at least attenuated by providing the organism with
negative entropy induced medicines, like for example those that
increase the free energy availability in the organism or induce
molecular organization –adaptogens & herbal tonics-. Work is being
undertaken to prove this point, by carrying out clinical studies in the
fifty most common chronic degenerative pathologies of which some
preliminary results in are mentioned in this paper.
The
author's final goal with his work is to prove the existence of a
workable general theory of living systems that Mds, healthcare
professionals and practitioners may safely and effectively utilize in
benefit of their primary objective: alleviate human suffering. Systemic
Theory establishes a logical framework under which phytotherapy, subtle
medicines and even orthodox medicines, can be administered with
clinical success, to chronic patients suffering from “incurable”
diseases. More importantly, it provides a systematic, simple and
accurate method of phytomedical application, for all those healthcare
practitioners who are disillusioned at the many iatrogenic results of
allopathic medicine or who have not inherited the art of traditional
medicine, since most accomplished herbalists, such as Maurice Messegue,
Dr. Lomidze, Balraj Maharishi…, etc, have inherited their extensive
family background in traditional medicine. (33)
Thus
Systemic Medicine is proposed as the answer to a quest for a rational
model for the application of herbal medicine. It also contributes to
understand and perhaps even redefine what the objective of a therapy
should be. Any therapeutic formula with phytomedicines -or other- must
comply with all four golden rules of Systemic Medicine: it should
provide Energy, Organizational and Biological Intelligence stimulators
and finally an emphasis should be placed on the etiological side,
determined by the pathology. |
|
Top^ |
VIII. References
1. Olalde J. Systemics : La Revolución de los Adaptógenos en la Salud. 2001. Caracas: Editorial Melvin C.A . (in Spanish )
2. Selye H. A syndrome produced by diverse nocuous agents. J Neuropsychiatry 1998; 10: 230-1.
3. Olalde J. Teoría Unificada de Systemics y más de 500 fórmulas terapéuticas. 2003. Caracas Editorial Adaptógenos Internacionales C.A . (in Spanish )
4. Olalde J. El Cáncer sí se cura. 2003. Caracas: Editorial: Adaptógenos Internacionales C.A . (in Spanish )
5. Selye H. Stress of Life. 1976. New York : McGraw-Hill
6. Brekhman II, Dardymov IV. New Substances of plant origin which increase non-specific resistance. Annu Rev Pharmacol . 1969; 9:419-30.
7. Khasina EI, Dardymov IV, Brekhman II. Effects of Eleutherococcus extract on the readaptation processes after 7 hour hypokinesia in rats. Kosm Biol Aviakosm Med. 1983; 17: 55 -8 .
8. Bhattacharya SK , Muruganandam AV . Adaptogenic activity of Withania somnifera : an experimental study using a rat model of chronic stress . Pharmacol Biochem Behav . 2003; 75: 547-55.
9. Dhuley JN . Adaptogenic and cardioprotective action of ashwagandha in rats and frogs. J Ethnopharmacol. 2000; 70: 57-63.
10. von Stockar U, Liu J. Does Microbial Life always feed on negative entropy? Thermodynamic analysis of microbial growth. Biochim Biophys Acat . 1999; 1412: 191-211 .
11. Korotkov K, Williams B, Wisneski LA. Assessing biophysical energy transfer mechanisms in living systems: the basis of life processes . J Altern Complement Med . 2004; 10: 49 -57.
12. Hubbard LR. Dianetics: The Modern Science of Mental Health . 1950. Los Angeles : Bridge Publishing
13.
Owens J, Van de Castle R. “Gas Discharge Visualization Technique:
Introduction to the concept of Energy Fields” In: Korotkov K, editor.
Measuring Energy Fields. 2004. Fair Lawn : Backbone publishing: 11-22.
14. Bradley, P (ed.) British Herbal Compendium. 1992. Bournemouth : British Herbal Medicine Association: 115-7.
15.
Krizhanovsky E, Tan Shiew C, Lim Kwong C. Study of Influence of
Energetic Preparation using GDV-graphy and POMS Test. In: Proceedings
of VIII Internat. Sci. Cong. on Bioelectrography. 2004: 40.
16. Nordenstrom, B. Exploring BCEC-Systems. Stockholm : Nordic Medical Publications 1998: 102.
17. Sodi Pallares D, Matykow JE. Molécula de la vida y nuestro tratamiento metabólico. Revista SMIBA . 2003; Vol. 2: 1. (in Spanish )
18.
Bulanova Y, Menyailo N. Information basis of Ageing of Living Systems.
In: Proceedings of VIII International Scientific Congress on
Bioelectrography. St. Petersburg : 2004, 38.
19. Teeguarden R. The Ancient Wisdom of the Chinese Tonic Herbs. 2000. New York : Warner Books.
20. Rotshteyn Y, Zito SW. Application of modified in vitro screening procedure for identifying herbals possessing sulfonylurea-like activity . J Ethnopharmacol. 2004; 93: 337-44.
21. Takeda K, Okomura K. CAM and NK Cells. eCAM 2004;1: 17-27.
22. Blalock JE A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiol Rev . 1989; 69: 1-32.
23. Cavagnaro J, Lewis RM. Bidirectional regulatory circuit between the immune and neuroendocrine systems. Year Immunol . 1989; 4: 241-52.
24. Kohguchi M, Kunikata T, Watanabe H, Kudo N et al. Immuno-potentiating effects of the antler shaped fruiting body of Ganoderma lucidum Biosci Biotechnol Biochem . 2004; 68: 881-7.
25. Kidd PM. The use of mushrooms glucans and proteoglycans in cancer treatment. Altern Med Rev . 2000; 5: 4-27.
26. Kumar V, Contran R, Robbins S. Basic Pathology. 1997, Buenos Aires: Mac Graw Hill Interamericana 165.
27. Patiño, JF. Oncología, caos, sistemas complejos adaptativos y estructuras disipativas . Rev Colomb Cir 2002; 17:5-9. (in Spanish )
28. Abbas Abul; Lichtman Andrew; Pober Jordan. Cellular and Molecular Immunology. 2002. Buenos Aires : Mcgraw-Hill Interamericana.
29. Klimek, R. Biology of cancer: thermodynamic answers to some questions. Neuro Endocrinol Lett . 2001; 22: 413-6.
30. Xin Y. Advances in the treatment of malignant tumours by electrochemical therapy (ECT). Eur J Surg Suppl. 1994;:31-5.
31. Antoshechkin A. Leuzea and your health. 2000. Clearwater, Ceptima Publishing Co,
32. Antoshechkin A. The primary adaptogens: powerful remedies of prophylactic medicine. 2001. Clearwater , Ceptima Publishing.
33. Cooper EL. Complementary and Alternative Medicine, When Rigorous, can be Science. eCam 2004 1: 1-4.
34. Vandebroek I, et al. Use of medicinal plants and pharmaceuticals by indigenous communities
in the Bolivian Andes and Amazon. Bull World Health Organ. 2004; 82:
243-50.
35. Olalde JA, Magarici M, Amendola F, del Castillo O. Diabetic Foot Improvement using Systemic Medicine's framework. Caracas , AEMC, 2004. (Available through adaptogen@cantv.net ).
36. Grogono AW, Woodgate DJ. Index for measuring health. Lancet. 1971; 2: 1024-6.
37. Wagner FW. The dysvascular foot: a system of diagnosis and treatment. Foot Ankle 1981; 2: 64-122.
38. Olalde JA, Magarici M, Amendola F, del Castillo O. Benefits of Systemic Medicine in patients with Severe Psoriasis. AEMC. Caracas , 2004. (Available through adaptogen@cantv.net ).
39. Olalde JA, Magarici M, Amendola F, del Castillo O. Improvement in Chronic Renal Failure
under Systemic Medicine framework. AEMC, Caracas 2004. (Available at adaptogen@cantv.net ).
40. Olalde JA, Magarici M, Amendola F, del Castillo O. Treatment of Terminal Prostate Cancer w/Systemic Medicine. AEMC, Caracas , 2004. (Available at adaptogen@cantv.net ).
41. Schwontkowski, D. Herbs of the Amazon. 1993. Science Student Brain Trust Publishing.
42. Kubota Y, Tanaka N, Umegaki K, Takenaka H, Mizuno H, Nakamura K, et al . Gingko biloba extract induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level. Life Sci . 2001;69:2327-36.
43. Auguet M, Delaflotte S. Pharmacological bases of the vascular impact of Gingko biloba extract. Presse Med. 1986;15: 1524-8 .
44. Pepe C, Rozza A, Veronesi G. The evaluation by video capillaroscopy of the efficacity of a Gingko biloba extract with L-arginine and magnesium in the treatment of trophic
lesions in patients with stage-IV chronic obliterating arteriopathy. Minerva Cardioangiol. 1999; 47: 223-30.
45. Jonadet M, Meunier MT , Bastide J. Anthocyanosides extracted for Vitis vinifera , Vaccinum myrtillus and Pinus maritimus . I. Elastase-inhibiting activities in vitro II. Compared angioprotective activities in vivo. J Pharm Belg 1983; 38: 41-6.
46. Detre Z, Jellinek H, Miskulin M, Robert AM. Studies on vascular permeability in hypertension: action of the anthocyanosides. Clin Physiol Biochem. 1986; 4:143-9.
47. Zaragoza F, Iglesias I, Benedi J . Comparative study of the anti-aggregation effects of anthocyanosides and other agents. Arch Farmacol Toxicol . 1985;11:138-8.
48. Savickiene N, Dagilyte A, Lukosius A. Importance of biologically active components and plants in the prevention of complications of diabetes mellitus. Medicina ( Kaunas ). 2002; 38: 970-5.
49. Chun YT, Yip TT, Lau KL, Kong YC. A biochemical study on the hypertensive effects of berberine in rats. Gen Pharmac 1978;10:177-182.
50. Marin-Nieto JA, Maciel BC , Secches AL, Gallo L. Cardiovascular effects of berberine in patients with severe congestive heart failure. Clin Cardiol 1988;11:253-260.
51. Kang DG, Sohn EJ, Kwon EK. Effects of berberine on angiotensin-converting enzyme and NO/cGMP system in vessels. Vascul Pharmacol . 2002; 39: 281-6.
52. Redman DA. Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report. J Altern Complement Med . 2000;6: 539-49.
53. Bouaziz N, Michiels C, Janssens D. Effects of Ruscus extract and hesperidin methylchalcone on hypoxia-induced activation of endothelial cells. Int Angiol. 1999; 18:306-12.
54. Incandela L, Cesarone MR, Cacchio M, Total triterpenic fraction of Centella asiática in chronic venous insufficiency and in high-perfusion microangiopathy. Angiology . 2001; 52 Suppl 2: S9-13.
55. Rigelsky JM, Sweet BV . Hawthorn: pharmacology and therapeutic uses. Am J Health Syst Pharm . 2002; 59; 417-22.
56. Fitzpatrick DF, Bing B, Rohdewald P. Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol. 1998; 32: 509-15.
57. La caille-Dubois, Franck U, Wagner H. Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants. Phytomedicine. 2001; 8: 47 -52.
58. Waki I, Kyo H, Yasuda M, et al. Effects of hypoglycemic component of ginseng radix on insulin biosynthesis in normal and diabetic animals. J Pharmacobyodin . 1982: 5: 547-54.
59. Zhouwand bx, Zhou QL, Yang M, et al. Hypoglacaemic mechanisms of ginseng glycopeptide. Acta Pharmacol Sin . 2003; 24: 61-6 .
60. Sotaniemi EA, Haapakoski F, Rautio A. Ginseng Therapy in non-insulin dependent diabetic patients Diabetes Care 1995; 18:1773-5.
61. Bates SH, Jones RB, Bailey CJ. Insulin-like effect of pinitol. Br J Pharmacol 2000;130:1944-8.
62. Zhang HN, Lin ZB. Hypoglycemic effect of Ganoderma lucidum polysaccharides Acta Pharmacol Sin 2004 ; 25:191-5.
63. Mukherjee D, Nissen SE, Toppol EJ. Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA. 2001; 286: 954-9.
64. Mukherjee D, Topol EJ. Cox-2: where are we in 2003? Cardiovascular risk and Cox-2 inhibitors. Arthritis Res Ther . 2003; 5:8-11.
65. Krum H, Liew D, Aw J, Hass S. Cardiovascular effects of selective cyclooxigenase-2 inhibitors. Expert Rev Cardiovasc Ther. 2004; 2:265-70
66. I nternational Herald Tribune. Bextra termed a `time bomb´ for Pfizer. Harris G. Nov.11. 2004.
67.
Chrubasik S, Model A, Black A, Pollack S. A randomized double blind
pilot study comparing Doloteffin and Vioxx in the treatment of lower
back pain. Rheumatology (Oxfrd). 2003;42:141-8.
68. Su C, Wang MY, Nowicky D, Jensen CJ, Anderson G. Selective COX-2 inhibition of Morinda citrifolia (Noni) in vitro. The proceedings of the Eicosanoids and other bioactive
lipids in cancer, inflammation and related disease. The 7 th Annual
Conference, 2001 Oct. 14-17. Nashville , USA .
69.
Hong CH et al. Evaluation of natural products on inhibition of
inducible cyclooxigenase (COX-2) and nitric oxide synthase (iNOS) in
cultured mouse macrophage cells. J Etnopharmacology . 2002; 83:153-9.
70. Tai WP, Luo HS. The inhibit effect of berberine in human colon cell line cyclooxygenase-2. Zhonghua Nei Ke Za Chi. 2003 ;42:558-60.
71. F ukuda K, et al. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Etnopharmacology. 1999;66:227-33.
72. Sandoval-Chacon M, et al. Anti-inflammatory action of cat's claw: the role of NF-kappaB. Aliment Pharmacol Ther . 1998 ;12:1279 -89. 73. Li, XY. Immunemodulating Chinese herbal medicines. Shanghai Institute of Materia Medica , Chinese Academy of Sciences. Mem Inst Oswaldo Cruz. 1991 ;86 Suppl 2:159-64.
74. Zhongguo Zhong, Xi Yi Jie, He Za Zhi. Effects of Astrágalus membranáceus and Tripterygium hypoglancum on natural killer cell activity of peripheral blood mononuclear in
systemic lupus erythematosus, Dept. of Dermatology, General Hospital of
Air Force, Beijing . 1992;12: 669-71.
75. Xin Y. Advances in the treatment of malignant tumors by electrochemical therapy (ECT). Eur J Surg Suppl. 1994; 574:31-5. |
|
IX. Addendums |
|
Addendum A |
|
Nature of Study |
Improvement |
QoL |
Tolerance |
Reduction of secondary effects´ morbidity in Breast Cancer Chemotherapy with Systemic Medicine (SM) |
Incidence of effects :
Nausea: 5.9%
Vomits: 2.9%
Diarrhea: 0%
Alopecia: 0% |
Neutropenia: 0%
Infections: 2.9%
Thrombocytopenia: 0%
Neuropathies: 0%
Myalgia: 0%
Estomatitis: 0% |
Average QoL: 91.18% (p< 0.00001)
|
100% |
Re-establishment of hepatic functionality in Chronic Liver disease with MS |
Reduction in :
Oxalacetic Transaminase (AST) 86.9%(p<0.014)
Pyruvic Transaminase (ALT) 86.9% (p<0.001)
Bilirubin: 96.4%(p<0.002) |
Average: 100%
(p<0.00001) |
100% |
Remission of Prostate Terminal CA w/SM |
Reduction of PSA:
76.6% (p < 0.091) |
Average: 86.6% (p<0.00001) |
96.6% |
Results of SM in Chronic Renal Failure (P) |
Reduction de : Seric Urea: 61.9% (p < 0.014)
Seric Creatinine: 69 % (p < 0.007) |
Average: 81.4% (p<0.00001) |
100% |
Results of SM in Chronic Renal Failure (R) |
Increase in Creatinine clearance ratio: 86.88% (p<0.0001) |
Average: 89.34% (p<0.00001) |
99.19% |
Improvement of Diabetic Neuropathy w/ SM (P) |
Decrease in symptoms associated w/ Neuropathy:
71.11% (p < 0.0001) |
Average: 77% (p<0.0001) |
100% |
Effectiveness of Systemic Medicine in Peripheral Diabetic Neuropathy (R) |
Reduction of symptoms associated w/ Neuropathy Peripheral Diabetes :
71% (p < 0.0001) |
Average: 90.4%
( p < 0.0009) |
99.44% |
Effectiveness of Systemic Medicine in Diabetic Neuropathy (P) |
Clinical improvement:
Pain: 81.8% (p< 0.00001)
Myalgia: 44.3% (p< 0.00001)
Distal Edema: 54.5% (p< 0.00006)
Sexual Dysfunction: 66.7% (p< 0.00001)
Hyperhidrosis: 39.4% (p< 0.0009) |
Average: 77%
( p < 0.00001) |
100% |
Improvements in Parkinson with Systemic Treatment |
Clinical improvement in most critical symptom:
Tremor: 74.65% (p< 0.00001) |
Average: 88.75%
(p< 0.00001) |
100% |
Remission of diabetic foot diagnosed w/amputation |
Clinical improvement:
100% (p < 0.03) |
Average:
100% (p<0.0001) |
100% |
Remission of diabetic foot Systemic Treatment |
Improvement of Symptoms:
77% (p<0.00001) |
Average:
84% (p<0.00001) |
96.7% |
Remission of psoriasis with
Systemic Medicine (P) |
Clinical Improvement of Symptoms:
68.89% ( p<0.00001) |
Average: 84.44%
(p<0.00001) |
96.11% |
Remission of severe Psoriasis
w/ Systemic Treatment |
Clinical improvement:
77.3% % (p<0.00001) |
Average:82.9%
(p<0.00001) |
100% |
Remission of varicose ulcers with Systemic Medicine |
Improvement: Lesions Size: 79%
Pain: 78% (p< 0.0001); Edema: 88.7% (p< 0.0001) |
Average: 81.3%
(p<0.00001) |
99.23% |
Clinical study to evaluate effectiveness of Systemic Medicine in Prostate Cancer patients |
Reduction of PSA: 100%
|
Average: 93.3% |
93.3% |
Improvement in Symptomatic Prostate Hyperplasia with Systemic Treatment |
Reduction in Prostate size : 71.73%
|
Average: 100% |
100% |
Prospective study to evaluate effectiveness of Artritina in patients with Knee Osteoarthritis |
Clinical improvement:: 96.6% |
Average:
96.6% |
100% |
|
|
|
|
|
|
|
|
|